2012 Fiscal Year Final Research Report
Etiological role of human papillomavirus infection in the development of urogenital tumor
| Project/Area Number |
23791748
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | ヒトパピローマウイルス / 性感染症 / 陰茎癌 / 膀胱癌 |
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| Research Abstract |
Firstly, as urine samples are suitable for large-scale studies of not only HPV but also other microorganisms that cause urethritis because of the ease and noninvasive nature of sampling, we have attempted to improve the analysis methods using urinary samples. We found that this method is applicable for detection of HPV in urine. In addition, eighty-four female patients with primary bladder tumor were studied. HPV-DNA was detected in 5 (6.0%) of 84 eligible patients, and we demonstrated that HPV infection is likely to play an important role in the development of female bladder tumorbased on various histopathological and molecular methods. Furthermore, we found that 47% of penile cancer was likely to be associated with penile HPV infection.
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