2012 Fiscal Year Final Research Report
The elucidation of ATP releasing pathway of bladder epithelial cell upon stretch stimulation
| Project/Area Number |
23791749
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | シグナル伝達 / 生理学 / 神経科学 |
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| Research Abstract |
We have investigated exocytotic release of ATP from urothelium, especially focusing on vesicular nucleotide transporter (VNUT). VNUT gene and protein was highly expressed in the epithelial layer of mouse bladder tissue and primary urothelial cell culture. The stretch-evoked ATP release was significantly reduced by the treatment of VNUT siRNA or several inhibitors of vesicular exocytosis. These findings suggest that VNUT plays an important role in stretch-elicited ATP release from urothelium.
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[Presentation] Vesicular nucleotide transporter (VNUT) is a key molecule for mechanosensing in the human urinary bladder: negative correlation between VNUT expression in human bladder mucosa and first desire to void2012
Author(s)
Nakagomi H, Mochizuki T, Miyamoto T, Kira S, Yoshiyama M, Kawahara K, Moriyama Y, Koizumi S, Takeda M
Organizer
(Abstract No. 12) International Continence Society 42nd Annual meeting, China National Convention Centre
Place of Presentation
Beijing, China
Year and Date
20121015-18
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[Presentation] VNUT (vesicular nucleotide transporter) plays a crucial role in stretch-evoked ATP release from urothelium2012
Author(s)
Nakagomi H, Mochizuki T, Miyamoto T, Yoshiyama M, Araki I, Moriyama Y, Koizumi S, Takeda M
Organizer
(Abstract No. 495, May 20, 2012) American Urological Association Annual Meeting, Georgia World Congress Center
Place of Presentation
Atlanta, Georgia, U.S.A
Year and Date
20120519-23
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[Presentation] Gene expression patterns of acid-sensing ion channels (ASICs) families in mammalian bladder2010
Author(s)
Kobayashi H, Yoshiyama M, Inuzuka H, Kira S, Nakagomi H, Miyamoto T, Haneda Y, Sawada N, Zakoji H, Tsuchida T, Araki I, Takeda M
Organizer
(Abstract No. 520) International Continence Society 40th/International Uro-Gynecology Association Joint Meeting
Place of Presentation
Toronto, Canada
Year and Date
20100823-27
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[Presentation] Hypertension and type 2 diabetes mellitus are highly associated with nocturia than metabolic syndrome in Japanese population2010
Author(s)
Imamura N, Nakagomi H, Yoda Y, Zakoji H, Kobayashi H, Tsuchida T, Fukazawa M, Yoshiyama M, Araki I, Takeda M
Organizer
(Abstract No. 381) International Continence Society 40th /International Uro-Gynecology Association Joint Meeting
Place of Presentation
Toronto, Canada
Year and Date
20100823-27
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