2012 Fiscal Year Final Research Report
Clarification of urination sensor system of the mouse bladder epithelia
| Project/Area Number |
23791754
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
|
| Keywords | 尿意センサー / 膀胱上皮細胞 / カルシウムイオンチャネル / 酸感受性 |
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| Research Abstract |
Common characters of known urination sensors are calcium channels and acid sensitivity. We gave acid stimuli to the mouse bladder epithelia under the condition that these channels were inhibited completely, and found calcium concentration increase of the cell inside by the stimulation pH < 5. It was suggested that this phenomenon was caused by the calcium entry from out of cells via calcium channel(s). The bladder epithelial cell response to acid stimuli was not observed in esophagus epithelial cells, that is, these findings indicated that the response mechanism to acid is specific to bladder epithelial cells.
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Research Products
(6 results)
