Doxycycline: new therapy for renal ischemia reperfusion injury

2012 Fiscal Year Final Research Report

• Project/Area Number: 23791758
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: Okayama University
• Principal Investigator: ARAKI Motoo 岡山大学, 岡山大学病院, 講師 (90467746)
• Research Collaborator: HIROHATA Satoshi 岡山大学, 国際センター, 准教授 (90332791) ; NINOMIYA Yoshifumi 岡山大学, 大学院・医歯薬学総合研究科, 教授 (70126241)
• Project Period (FY): 2011 – 2012
• Keywords: 腎虚血再潅流障害 / ドキシサイクリン / 細胞外マトリックス(MMP) / MMP 阻害薬 / 腎移植

Research Abstract

The protective effect of doxycycline was examined in murine renal ischemia reperfusion injury (IRI) model. The administration ofdoxycycline reduce renal IRI confirmed by reduced serum creatinine level and damage in histopathology. The mechanism was due to reduced neutrophil infiltration in renal tissue by matrix metalloproteinases (MMPs) inhibition by doxycycline.

Research Products

• [Journal Article] Laparoscopic-assisted tension-free vaginal mesh: an innovative approach to placing synthetic mesh (2012)
  • Author(s): Watanabe T, Inoue M, Ishii A, Yamato T, Yamamoto M, Sasaki K, Kobayashi Y, Araki M, Uehara S, Saika T, Kumon H
  • Journal Title: transvaginally for surgical correction of pelvic organ prolapse Volume: 66 Pages: 23-29
  • Peer Reviewed
• [Journal Article] The clinical impact of pathological review on selection the treatment modality for localized prostate cancer in candidates for brachytherapy monotherapy (2012)
  • Author(s): Kishimoto R, Saika T, Bekku K, Nose H, Abarzua F, Kobayashi Y, Araki M,Yanai H, Nasu Y, Kumo n H
  • Journal Title: World J Urol Volume: 30 Pages: 375-378
  • Peer Reviewed
• [Journal Article] Ureteroscopic management of chronic unilateral hematuria (2012)
  • Author(s): Araki M, Uehara S, Sasaki K, Monden K, Tsugawa M, Watanabe T, Monga M, Nasu Y, Kumon H
  • Journal Title: a single-center experience over 22 years Volume: 7 Pages: e36729
  • Peer Reviewed
• [Journal Article] Laparoscopic management of complicated urachal remnants in adults (2012)
  • Author(s): Araki M, Saika T, Araki D, Kobayashi Y, Uehara S, Watanabe T, Yamada K, Nasu Y, Kumon H
  • Journal Title: World J Urol Volume: 30 Pages: 647-650
  • Peer Reviewed
• [Journal Article] Nerve growth factor level in the prostatic fluid of patients with chronic prostatitis/chronic pelvic pain syndrome is correlated with symptom severity and response to treatment (2011)
  • Author(s): Watanabe T, Inoue M, Sasaki K, Araki M,Uehara S, Monden K, Saika T, Nasu Y, Kumon H, Chancellor MB
  • Journal Title: BJU Int Volume: 108 Pages: 248-251
  • Peer Reviewed
• [Journal Article] Detection and isolation of nanobacteria-like particles from urinary stones (2011)
  • Author(s): Kumon H, Matsumoto A, Uehara S, Abarzua F, Araki M, Tsutsui K, Tomochika K
  • Journal Title: long-withheld data. Int J Urol Volume: 18 Pages: 458-465
  • Peer Reviewed
• [Presentation] 血液凝固第8因子の活性亢進を伴うレシピエントに施行した生体腎移植の1例 (2011)
  • Author(s): 有吉勇一,荒木元朗,岸本 涼,和田耕一郎,小林泰之,江原 伸,上原慎也,渡辺豊彦,那須保友,公文裕巳
  • Organizer: 第63回日本泌尿器科学会西日本総会
  • Place of Presentation: 久留米市
  • Year and Date: 2011-11-10
• [Presentation] 基調講演II 腎移植の現状と進歩 (2011)
  • Author(s): 荒木元朗
  • Organizer: 第61回岡山腎疾患懇話会
  • Place of Presentation: 岡山市
  • Year and Date: 2011-10-08
• [Presentation] 岡山大学泌尿器科における腎移植初期症例の検討 (2011)
  • Author(s): 荒木元朗,和田耕一郎,有吉勇一,上松克利,河内啓一郎,小武家誠,上原慎也,渡辺豊彦,雑賀隆史,那須保友,公文裕巳
  • Organizer: 第47回日本移植学会総会
  • Place of Presentation: 仙台市
  • Year and Date: 2011-10-04
• [Presentation] 拡張型心筋症を伴った生体腎移植の1例 (2011)
  • Author(s): 荒木元朗,上松克利,河内啓一郎,小武家誠,上原慎也,渡辺豊彦,雑賀隆史,那須保友,公文裕巳
  • Organizer: 第27回腎移植・血管外科研究会
  • Place of Presentation: 札幌市
  • Year and Date: 2011-06-24
• [Presentation] Ureteroscopic evaluation and treatment of chronic unilateral hematuria: A 24 year experience (2011)
  • Author(s): Araki M.,Uehara S.,Monden K.,Watanabe T.,Saika T.,Nasu Y.,Kumon H
  • Organizer: 106th American Urological Association 2011 Annual Meeting
  • Place of Presentation: Washi ngton, DC, USA
  • Year and Date: 2011-05-14
• [Presentation] 腎虚血再灌流傷害におけるドキシサイクリンによる腎障害抑制効果の検討 (2011)
  • Author(s): 河内啓一郎,上松克利,荒木元朗,石井和史,上原慎也,渡辺豊彦,雑賀隆史,那須保友,公文裕巳,二宮善文,廣畑 聡,三好 亨
  • Organizer: 第99回日本泌尿器科学会総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2011-04-21
• [Presentation] 岡山大学泌尿器科における腎移植初期症例の検討 (2011)
  • Author(s): 荒木元朗,上松克利,河内啓一郎,小武家誠,上原慎也,渡辺豊彦,雑賀隆史,那須保友,公文裕巳,齋藤和英,高橋公太
  • Organizer: 第99回日本泌尿器科学会総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2011-04-21