2014 Fiscal Year Final Research Report
Characterization of the low pH-resistant LNCaP cell subline
| Project/Area Number |
23791768
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Gifu Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Keywords | LNCaP細胞 / LNCaP-F10細胞 / 細胞外低pH / アポトーシス |
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| Outline of Final Research Achievements |
Intratumoral region of low extracellular pH is common feature of solid tumors. The subline LNCaP-F10, of the prostate cancer cell line LNCaP, was isolated and its low pH-resistant property was examined. LNCaP-F10 cells were grown under low-pH condition, which caused apoptosis of the LNCaP cells. Significant differences in the expression of TNFSF10, BIRC5 and CASP10 were detected between LNCaP-F10 and LNCaP cells. These factors were related with the apoptosis induction by extracellular low pH.
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| Free Research Field |
泌尿器科学，薬局薬学
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