2012 Fiscal Year Final Research Report
The role of bladder microcirculation and Kit positive interstitial cells in OAB
| Project/Area Number |
23791769
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Nagoya City University |
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Principal Investigator |
KUBOTA Yasue 名古屋市立大学, 大学院・医学研究科, 講師 (00381830)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 過活動膀胱 / 間質細胞 |
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| Research Abstract |
In the gastrointestinal tract, interstitial cells of Cajal (ICC) act as primary pacemaker cells, and play a fundamental role in the transmission of signals from enteric neurons to smooth muscle cells. In the urinary tract, including bladder, ICCs, which are referred to as interstitial cells (IC), ICC-like cells, or myofibroblasts, have also been identified by their morphological characteristics, but represent variability among tissues which may account for individual characteristics of organ. ICCs express the proto-oncogene c-kit, and signaling via the receptor kinase gene product, KIT, which is used as an identification marker of ICCs. Recent reports have suggested that KIT is not only a detection marker of these cells, but also may play a crucial role in the control of bladder function. Identifying the functions of ICCs and/or KIT may be a shortcut to clarify the pathophysiology of overactive bladder (OAB) and detrusor overactivity. Thus, in this study, we summarize the distribution and function of KIT-positive ICC and KIT in the bladder as well as the association between KIT-positive ICCs or KIT and OAB, and discuss the possible therapeutic target of KIT for OAB in the future. Finally, we demonstrated the usefulness of a possible objective biomarker for diagnosis and treatment efficacy, stem cell factor (SCF), which is a natural ligand for KIT.
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Research Products
(25 results)
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[Journal Article] Adiponectin ameliorates kidney stone formation in metabolic syndrome model mice by inhibition of inflammation and apoptosis.2013
Author(s)
Yasuhiro Fujii, Atsushi Okada, Takahiro Yasui, Kazuhiro Niimi, Shuzo Hamamoto, Masahito Hirose, Yasue Kubota, Yoshiyuki Kojima, Keiichi Tozawa, Yutaro Hayashi, and Kenjiro Kohri.
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Journal Title
Journal of biological chemistry
Volume: 8(4)
Pages: e61343
DOI
Peer Reviewed
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[Journal Article] Mitochondrial permeability transition pore opening induces the initial process of renal calcium crystallization2012
Author(s)
Niimi Kazuhiro, Yasui Takahiro, Hamamoto Shuzo, Itoh Yasunori,Okada Atsushi, Kubota Yasue, Kojima Yoshiyuki, Tozawa Keiichi, Sasaki Shoichi, Hayashi Yutaro, Kohri Kenjiro.
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Journal Title
Free Radic Biol Med
Volume: 52(7)
Pages: 1207-17
DOI
Peer Reviewed
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[Journal Article] Role of osteopontin in early phase of renal crystal formation: immunohistochemical and microstructural comparisons with osteopontin knock-out mice2012
Author(s)
Hirose Masahito, Tozawa Keiichi, Okada Atsushi, Hamamoto Shuzo, Higashibata Yuji, Gao Bin, Hayashi Yutaro, Shimizu Hideo, Kubota Yasue, Yasui Takahiro, Kohri Kenjiro
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Journal Title
Urol Res
Volume: 40(2)
Pages: 121-129
DOI
Peer Reviewed
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[Journal Article] TRPM8-expressing dorsal root ganglion neurons project dichotomizing axons to both skin and bladder in rats2011
Author(s)
Shibata Yasuhiro, Ugawa Shinya, Imura Makoto, Kubota Yasue, Ueda Takashi, Kojima Yoshiyuki, Ishida Yusuke, Sasaki Shoichi, Hayashi Yutaro, Kohri Kenjiro, Shimada Shoichi.
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Journal Title
Neuroreport
Volume: 22(2)
Pages: 61-67
DOI
Peer Reviewed
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