2013 Fiscal Year Final Research Report
Solution of the antitumor effect and clinical trials of the peptide vaccine therapy for renal cel carcinoma and bladder cancer
Project/Area Number |
23791781
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Urology
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Research Institution | Iwate Medical University |
Principal Investigator |
OBARA Wataru 岩手医科大学, 医学部, 講師 (90337155)
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Project Period (FY) |
2011 – 2013
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Keywords | がんペプチドワクチン療法 |
Research Abstract |
We investigated the predictive factor associated with the effect of the peptide vaccine treatment using clinical specimen. The expression of MPHOSPH1 and DEPDC1 antigen were recognized in all cases, but there was no correlation between expression intensity and grade and stage of the tumor. Cases 80% or more showed CTL induction after vaccination, and the CTL induction was maintained during follow-up period. The patient in recognition of the response of the vaccine administration site showed a decrease of the recurrence rate as compared with an absent case. Performance Status, CTL induction and injection site reaction were identified as an associated factor of the peptide vaccine treatment.
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[Presentation] A Phase I/II study of cancer peptide vaccine S-288310 in patients with advanced urothelial carcinoma2013
Author(s)
Obara W, Mitsuhata N, Mimata H, Eto M, Kohri K, Miura I, Shuin T, Miki T, Fujimoto H, Fujioka T
Organizer
The European Cancer Congress 2013
Place of Presentation
Amsterdam, Netherlands
Year and Date
20131000
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[Presentation] シンポジウム : がんペプチドワクチンによる筋層非浸潤膀胱癌に対する術後アジュバント療法(多施設共同第2相臨床研究)2011
Author(s)
小原航,光畑直喜,安富祖久明,西光雄,那須誉人,執印太郎,三木恒治,三股浩光,原勲,吉田浩二,角田卓也,中村祐輔,藤岡知昭
Organizer
第24回日本バイオセラピィ学会学術集会総会
Place of Presentation
和歌山
Year and Date
20111200
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[Presentation] ワークショップ : 筋層非浸潤膀胱癌の再発予防を目的としたがんペプチドワクチン療法(第2相臨床研究)2011
Author(s)
小原航,光畑直喜,安富祖久明,西光雄,那須誉人,執印太郎,三木恒治,三股浩光,原勲,吉田浩二,角田卓也,中村祐輔,藤岡知昭
Organizer
第49回日本癌治療学会学術集会
Place of Presentation
名古屋
Year and Date
20111000
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