2012 Fiscal Year Final Research Report
The relationship between microenvironment and growth of the cellsregulated by EBAG9 in bladder cancer
| Project/Area Number |
23791783
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 腫瘍学 / EBAG9 / がん / 微小環境変化 / 腫瘍免疫 |
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| Research Abstract |
Mouse bladder cancer cells were subcutaneously implanted into Ebag9 knockout mice and control mice. We found that tumor volumes generated in Ebag9 knockoutmice were smaller than that of control mice. Furthermore, numbers of T cell infiltration increased in implanted tumors of Ebag9 knockout mice. We analyzed the expression of immune-related genes in the T cells derived from tumors using qPCR. Notably, tumor metastasis in lung was suppressed in Ebag9 knockout mice. We assume that EBAG9 may regulate tumor growth and migration by regulating immune response of host cells.
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