2012 Fiscal Year Final Research Report
A new strategy controlling of AKT-mTOR pathway with targeting to progression of castration resistant prostate cancer.
| Project/Area Number |
23791787
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Keio University |
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Principal Investigator |
YASUMIZU Yota 慶應義塾大学, 医学部, 助教 (40464854)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 去勢抵抗性前立腺癌 / PI3K/AKT/mTOR pathway / ドセタキセル抵抗性 / Dual PI3K/mTORC1/2阻害剤 |
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| Research Abstract |
In this study we explored the efficacy of a AKT-mTOR pathway inhibitor for docetaxel resistant prostate cancer cell line: C4-2AT6. C4-2AT6 cells revealed combined administration of AKT-mTOR pathway inhibitor and docetaxel had a significant and synergistic
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