2012 Fiscal Year Final Research Report
Liposomal IL-21/IL-15 Gene Therapy in an Orthotopic Bladder Cancer Model and Prevention of Tumor Invasion and Metastasis
| Project/Area Number |
23791788
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Keio University |
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Principal Investigator |
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| Research Collaborator |
MATSUMOTO Kazuhiro 慶應義塾大学, 医学部, 助教 (80366153)
KIKUCHI Eiji 慶應義塾大学, 医学部, 講師 (10286552)
MIYAJIMA Akira 慶應義塾大学, 医学部, 講師 (90245572)
OYA Mototsugu 慶應義塾大学, 医学部, 教授 (00213885)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 膀胱癌 / インターロイキン21 / 遺伝子導入 / 膀胱内注入 |
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| Research Abstract |
We transfected IL-21 plasmid to MBT2 cells, and the supernatant IL-21 level was measured by ELISA after the transfection of IL-21 gene. The peak IL-21level was observed 24 hr after the transfection of IL-21 plasmids. Next, we established the orthotopic bl
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