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2013 Fiscal Year Final Research Report

Construction of the tailor-made medicine for prostate cancer with bone metastasis using bone turnover metabolites

Research Project

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Project/Area Number 23791792
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Urology
Research InstitutionToho University

Principal Investigator

KAMIYA Naoto  東邦大学, 医学部, 講師 (40436431)

Project Period (FY) 2011 – 2013
Keywords前立腺 / 骨転移 / MMP / 骨代謝マーカー
Research Abstract

Serum MMP-2 level correlated with tumor grade and the extent of bone metastases in prostate cancer (PCa) with bone metastases. We determined that the additive effect of zoledronic acid (ZA) on serum PSA and bone turnover markers changes for hormone-sensitive PCa patients with bone metastasis treated by combined androgen blockade (CAB). The addition of ZA to CAB therapy showed PSA and ALP response compared with CAB therapy only, suggesting a potential antitumor effect of ZA in the management of metastatic PCa patients.
Furthermore, to clarify clinical predictors for a PSA decrease >50% in response to alternative non-steroidal antiandrogen therapy (AA) and to develop a nomogram to predict the PSA decrease >50% in response to AA in patients with advanced PCa that relapsed after initial CAB. The receiver operating characteristic curve showed that the accuracy of the predicted probability was 72.5% for the model.

  • Research Products

    (20 results)

All 2013 2012 2011

All Journal Article (6 results) (of which Peer Reviewed: 5 results) Presentation (10 results) Book (4 results)

  • [Journal Article] Clinical outcomes by relative docetaxel dose and dose intensity as chemotherapy for Japanese patients with castration-resistant prostate cancer : a retrospective multi-institutional collaborative study2013

    • Author(s)
      Kamiya N, Suzuki H, et al
    • Journal Title

      Int J Clin Oncol

      Volume: (Epub ahead of print)

    • Peer Reviewed
  • [Journal Article] Clinical usefulness of bone markers in prostate cancer with bone metastasis2012

    • Author(s)
      Kamiya N, Suzuki H, et al
    • Journal Title

      Int J Urol

      Volume: 19 Pages: 968-979

    • Peer Reviewed
  • [Journal Article] Additive effect of zoledronic acid on serum prostate-specific antigen changes for hormone-sensitive prostate cancer patients with bone metastasis treated by combined androgen blockade2012

    • Author(s)
      Kamiya N, Suzuki H, et al
    • Journal Title

      Int J Urol

      Volume: 19 Pages: 169-173

    • Peer Reviewed
  • [Journal Article] 前立腺癌骨転移症例に対する血清破骨細胞活性マーカーの臨床的意義2012

    • Author(s)
      神谷直人,鈴木啓悦, 他
    • Journal Title

      日本腎泌尿器疾患予防医学研究会誌

      Volume: 20 Pages: 75-77

  • [Journal Article] Significance of serum osteoprotegerin and receptor activator of nuclear factor kappa B ligand in Japanese prostate cancer patients with bone metastasis2011

    • Author(s)
      Kamiya N, Suzuki H, et al
    • Journal Title

      Int J Clin Oncol

      Volume: 16 Pages: 366-372

    • Peer Reviewed
  • [Journal Article] 前立腺癌骨転移症例における血清骨代謝マーカーの臨床的意義2011

    • Author(s)
      神谷直人,鈴木啓悦, 他
    • Journal Title

      日本腎泌尿器疾患予防医学研究会誌

      Volume: 19 Pages: 93-94

    • Peer Reviewed
  • [Presentation] 再燃前立腺癌における抗アンドロゲン剤交替療法の有用性を予測する検討NASA-PC-PM2013

    • Author(s)
      神谷直人
    • Organizer
      第51回日本癌治療学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2013-10-26
  • [Presentation] CLINICAL OUTCOMES BY RELATIVE DOCETAXEL DOSE AND DOSE INTENSITY AS CHEMOTHERAPY WITH CASTRATIONRESISTANT PROSTATE CANCER : A RETROSPECTIVE MULTI-INSTITUTIONAL COLLABORATIVE STUDY2013

    • Author(s)
      Naoto Kamiya
    • Organizer
      America Urological Association Annual Meeting
    • Place of Presentation
      San Diego
    • Year and Date
      2013-05-06
  • [Presentation] Additive ellect of zoledronic acid on serum prostate-specilic antigen changes for hormone-sensitive prostate cancer patients with bone metastasis treated by combined androgen blockade2012

    • Author(s)
      Naoto Kamiya
    • Organizer
      15th International Congress on Hormonal Steroids and Hormones & Cancer
    • Place of Presentation
      金沢
    • Year and Date
      2012-11-16
  • [Presentation] 未治療前立腺癌骨転移症例に対するゾレドロン酸の臨床学的意義2012

    • Author(s)
      神谷直人
    • Organizer
      第50回日本癌治療学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2012-10-26
  • [Presentation] CLINICAL OUTCOMES OF SERUM BONE TURNOVER MARKERS IN PROSTATE CANCER WITH BONE METASTASIS2012

    • Author(s)
      Naoto Kamiya
    • Organizer
      America Urological Association Annual Meeting
    • Place of Presentation
      Atlanta
    • Year and Date
      2012-05-23
  • [Presentation] 未治療前立腺癌骨転移症例に対するゾレドロン酸の有用性2012

    • Author(s)
      神谷直人
    • Organizer
      第100回日本泌尿器科学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2012-04-23
  • [Presentation] 未治療前立腺癌骨転移症例に対するゾレドロン酸の有用性2011

    • Author(s)
      神谷直人
    • Organizer
      第49回日本癌治療学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-28
  • [Presentation] 去勢抵抗性前立腺癌に対するドセタキセル療法の臨床学的検討~多施設共同研究~2011

    • Author(s)
      神谷直人
    • Organizer
      第49回日本癌治療学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-27
  • [Presentation] 前立腺癌骨転移症例に対する血清破骨細胞活性マーカーの臨床学的意義2011

    • Author(s)
      神谷直人
    • Organizer
      第20回日本腎泌尿器疾患予防医学研究会
    • Place of Presentation
      前橋
    • Year and Date
      2011-07-08
  • [Presentation] 未治療前立腺癌骨転移症例に対するゾレドロン酸療法の意義2011

    • Author(s)
      神谷直人
    • Organizer
      第99回日本泌尿器科学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-04-24
  • [Book] 抗がん薬の臨床薬理2013

    • Author(s)
      神谷直人, 他
    • Total Pages
      334
    • Publisher
      南山堂
  • [Book] 前立腺癌と男性骨粗鬆症最新骨管理マニュアル2012

    • Author(s)
      神谷直人, 他
    • Total Pages
      155
    • Publisher
      医学図書出版
  • [Book] 成功・失敗の傾向,各疾患の特徴からつかむ臨床試験計画とデザインの設定2012

    • Author(s)
      神谷直人, 他
    • Total Pages
      242
    • Publisher
      技術情報協会
  • [Book] 前立腺癌のすべて第3版2011

    • Author(s)
      神谷直人, 他
    • Total Pages
      346
    • Publisher
      メディカルビュー社

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Published: 2015-06-25  

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