2012 Fiscal Year Final Research Report
Roles of branched-type disialyl- antigen in malignant conversion in renal cell cancer
| Project/Area Number |
23791796
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | The Noguchi Institute |
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Principal Investigator |
TSUCHIDA Akiko 公益財団法人野口研究所, 研究部, 研究員 (70378024)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 腎癌 / 糖脂質 / 糖転移酵素 / ジシアリル糖鎖 / 腫瘍マーカー |
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| Research Abstract |
Flow cytometric analysis of RCCs revealed that GalNAc-DSLc4 is presented on the cell surface in 70% of RCC lines. To investigate the roles of GalNAc-DSLc4 antigen in RCC, we prepared GalNAc-DSLc4-overexpressing transfectant cells using VMRC-RCW cells. They showed increased proliferation and invasion activities, and specific adhesion onto laminin-coating plates. These results suggest that GalNAc-DSLc4 is, at least partly, involved in the malignant properties of RCCs. And recently, we found that PI3K inhibitor (LY294002) suppresses malignant phenotype in GalNAc-DSLc4-overexpressing transfectant.
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[Journal Article] pp-GalNAc-T13 induces high metastatic potential of murine Lewis lung cancer by generating trimeric Tn antigen2012
Author(s)
Matsumoto Y, Zhang Q, Akita K, Nakada H, Hamamura K, Tokuda N, Tsuchida A, Matsubara T, Hori T, Okajima T, Furukawa K, Urano T, Furukawa K.
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Journal Title
Biochem Biophys Res Commun
Volume: 419(1)
Pages: 7-13
DOI
Peer Reviewed
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