2012 Fiscal Year Final Research Report
Development of therapeutic agent for uterine leiomyoma using a novel mouse model of human uterine leiomyoma.
| Project/Area Number |
23791800
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Obstetrics and gynecology
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
TSUIJI Kenji 東北大学, 大学院・医学系研究科, 助手 (40528155)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | 子宮筋腫 / 移植モデルマウス / クルクミン / ナノクルクミン / アポトーシス |
|---|
| Research Abstract |
Inhibitory effect of curcumin on uterine leiomyoma has been verified both in vitro and in vivo. The results showed that curcumin inhibited rat uterine leiomyoma cell proliferation by arresting cell cycle in vitro study. In vivo study, curcumin inhibited the cell proliferation of xenografts and nano-curcumin showed highly absorbent rate from the intestinal absorption compared with curcumin in the mouse model transplanted of human uterine leiomyoma.
|
