2013 Fiscal Year Final Research Report
Identification of new molecular target for ovarian cancer via functional genomic analysis
| Project/Area Number |
23791801
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Tohoku University |
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Principal Investigator |
TOYOSHIMA Masafumi 東北大学, 医学(系)研究科(研究院), 大学院非常勤講師 (70451581)
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| Project Period (FY) |
2011 – 2013
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| Keywords | c-Myc / 卵巣がん / siRNAスクリーニング / 合成致死 / CK1e / WEE1 / AuroraA / FURIN |
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| Research Abstract |
We searched new molecular target with a synthetic lethal effect with the high expression of oncogene c-Myc in ovarian cancer via large scale siRNA screening. Through bioinformatics analysis utilizing network analysis and database, and verification experiments both in vitro and in vivo, we identified CK1e, WEE1, Aurora A and FURIN as candidates molecule for the new therapeutic target.
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[Journal Article] Paclitaxel–carboplatin for advanced or recurrent carcinosarcoma of the uterus : the Japan Uterine Sarcoma Group and Tohoku Gynecologic Cancer Unit Study2014
Author(s)
Tadao Takano, Takeo Otsuki, Hideki Tokunaga, Masafumi Toyoshima, Hiroki Utsunomiya, Satoru Nagase, Hitoshi Niikura, Kiyoshi Ito, Nobuo Yaegashi, Hidekazu Yamada, Toru Tase, Masahiro Kagabu, Tadahiro Shoji, Toru Sugiyama, Naoki Sato, Toshio Fujimoto, Yukihiro Terada, Kenji Nakahara, Hirohisa Kurachi, Yoshihito Yokoyama, Hideki Mizunuma, Shu Soeda, Hiroshi Nishiyama, Takashi Matsumoto, Shinya Sato, Muneaki Shimada, Junzo Kigawa
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Journal Title
Int J Clin Oncol
Volume: (PMID : 24395448)
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[Journal Article] Clinical outcome of pelvic exenteration in patients with advanced or recurrent uterine cervical cancer2014
Author(s)
Tanaka S, Nagase S, Kaiho-Sakuma M, Nagai T, Kurosawa H, Toyoshima M, Tokunaga H, Otsuki T, Utsunomiya H, Takano T, Niikura H, Ito K, Yaegashi N
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Journal Title
Int J Clin Oncol
Volume: 19(1)
Pages: 133-8
DOI
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[Journal Article] Small Cell Carcinoma of the Uteruine Cervix : Clinical Outcome of concurrent Chemoradiotherapy with a Multidrug Regimen2013
Author(s)
Hideki Tokunaga, Satoru Nagase, Kosuke Yoshinaga, Sota Tanaka, Tomyuki Nagai, Hiroki Kurosawa, Michiko Kaiho-Sakuma, Masafumi Toyoshima, Takeo Otsuki, Hiroki Utsunomiya, Tadao Takano, Hitoshi Niikura, Kiyoshi ito and Nobuo Yaegashi
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Journal Title
Tohoku J. Exp. Med.
Volume: 229(1)
Pages: 75-81
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[Journal Article] Functional Genomics Identifies Therapeutic Targets for MYC-Driven2012
Author(s)
Masafumi Toyoshima , Heather L Howie , Maki Imakura , Ryan M Walsh , James E Annis , Aaron N. Chang , Jason Frazier , B Nelson Chau , Andrey Loboda , Peter S Linsley , Michele A. Cleary , Julie R Park , Carla Grandori
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Journal Title
Cancer PNAS
Volume: 109(24)
Pages: 9545-9550
DOI
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[Journal Article] Hysterescopic inspection and total curettage are insufficient for discriminating endometrial cancer from atypical endometrial hyperplasia2012
Author(s)
Hiroki Kurosawa, Kiyoshi ito, Hitoshi Nikura, Tadao Takano, Satoru Nagase, Hiroki Ustunomiya, Takeo Otsuki, Masafumi Toyoshima, Tomoyuki Nagai, Souta Tanaka, Mika Watanabe and Nobuo Yaegashi
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Journal Title
Tohoku J. Exp. Med.
Volume: 228(4)
Pages: 365-370
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