• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2013 Fiscal Year Final Research Report

Functional analysis of MAT2A in ovarian cancer development

Research Project

  • PDF
Project/Area Number 23791804
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Obstetrics and gynecology
Research InstitutionTohoku University

Principal Investigator

OTSUKI Takeo  東北大学, 医学(系)研究科(研究院), 非常勤講師 (40531330)

Project Period (FY) 2011 – 2013
Keywordsエピジェネティクス / 卵巣がん / MAT2A
Research Abstract

Genome-wide epigenetic changes are involved in human ovarian cancer. In this study, we found that MAT2A (methyonine adenosyltransferase 2A), which produces a methyl donor for transmethylation and plays an important role in DNA and histone methylation, is highly expressed and its gene body region is hypomethylation in human ovarian cancer cells. MAT2A siRNA and its inhibitor (cycloroicine) suppressed ovarian cancer cell growth. We found that tumor suppressor gene RB1 is a molecular target of MAT2A for human ovarian cancer. Our data suggest that RB1 is the new tumor maker of human ovarian cancer.

  • Research Products

    (2 results)

All 2014 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results)

  • [Journal Article] A phase I study of irinotecan and pegylated liposomal doxorubicin in recurrent ovarian cancer. (Tohoku Gynecologic Cancer Unit 104 study)2014

    • Author(s)
      Shoji T, Takatori E, Kaido Y, Omi H, Yokoyama Y, Mizunuma H, Kaiho M, Otsuki T, Takano T, Yaegashi N, Nishiyama H, Fujimori K, Sugiyama T
    • Journal Title

      Cancer Chemother Pharmacol

      Volume: 73(5) Pages: 895-901

    • DOI

      10.1007/s00280-014-2418-8

    • Peer Reviewed
  • [Journal Article] Small cell carcinoma of the uterine cervix : clinical outcome of concurrent chemoradiotherapy with a multidrug regimen2013

    • Author(s)
      Tokunaga H, Nagase S, Yoshinaga K, Tanaka S, Nagai T, Kurosawa H, Kaiho-Sakuma M, Toyoshima M, Otsuki T, Utsunomiya H, Takano T, Niikura H, Ito K, Yaegashi N
    • Journal Title

      Tohoku J Exp Med

      Volume: 229(1), PMID:23269283 Pages: 75-81

    • Peer Reviewed

URL: 

Published: 2015-06-25  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi