2013 Fiscal Year Final Research Report
Molecular analysis of growth of endometoriotic tissue affected by local estrogen production
| Project/Area Number |
23791805
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | SF-1 / 子宮内膜症 / エストロゲン / アロマターゼ / StAR / 正常子宮内膜 |
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| Research Abstract |
Steridgenic factor-1 plays a key-role for local estrogen synthesis in endometriotic stromal cells. Induction of SF-1 gene in endometrial stromal cells increased expression of StAR mRNA and protein but not other targets of SF-1. These results suggests gene group that regulates estrogen synthesis needs not only SF-1 gene expression but other factors.
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