2012 Fiscal Year Final Research Report
The relationship between ovarian function and expression of Mvk
| Project/Area Number |
23791807
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Gunma University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 卵巣 / ゴナドトロピン / 脂質代謝 / 機能調節 |
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| Research Abstract |
It has been reported that Mvk binds to LHR mRNA and stimulates the digestion of this mRNA as post-translational regulation. The production of Mvk was inhibited by E2 and stimulated by IL-6 and TNFα in granulosa cell culture.In the uterus, Mvk expression decreased after hCG treatment of immature rats. These results suggest that functional LHR are present in the uterus and are downregulated by hCG induced hCG.
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