2013 Fiscal Year Final Research Report
Application and evaluation of proteasome Inhibitor MG132-loaded polymeric micelle using in vivo imaging technique
| Project/Area Number |
23791812
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MATSUMOTO Yoko 東京大学, 医学部附属病院, 助教 (10466758)
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| Project Period (FY) |
2011 – 2013
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| Keywords | ドラッグデリバリーシステム / 子宮頸がん / プロテアソームインヒビター |
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| Research Abstract |
Proteasome inhibitor (PI) is attracting considerable attention as a new antitumor drug. We developed polymeric micelles incorporating PI MG132 with PEG polymers (MG132/m) to increase the antitumor effect and reduce strong side effects of PI. Subcutaneous xenograft mice models with human cervical cancer were established and were treated with MG132 or MG132/m. MG132/m had a stronger growth inhibitory effect compared to naked MG132. To analyze biodistribution of MG132 and MG132/m, we used intravital real-time confocal laser scanning microscopy (IVRTCLSM), which demonstrated that MG132/m had prolonged blood circulation and effective accumulation into tumors.
Core-shell type micelles could be an outstanding drug delivery system for MG132 and possibly other PIs in the treatment of cervical cancer.
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Research Products
(15 results)
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[Journal Article] Anti-tumor activity of olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, in cultured endometrial carcinoma cells2014
Author(s)
A. Miyasaka, K. Oda, Y. Ikeda, O. Wada-Hiraike, T. Kashiyama, A. Enomoto, N. Hosoya, T. Koso, T. Fukuda, K. Inaba, K. Sone, Y. Uehara, R. Kurikawa, K. Nagasaka, Y. Matsumoto, T. Arimoto, S. Nakagawa, H. Kuramoto, K. Miyagawa, T. Yano, K. Kawana, Y. Osuga, T. Fujii
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Journal Title
BMC cancer
Volume: 14
Pages: 179
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[Journal Article] Matrix metalloproteinase (MMP)-9 in cancer-associated fibroblasts (CAFs) is suppressed by omega-3 polyunsaturated fatty acids in vitro and in vivo2014
Author(s)
A. Taguchi, K. Kawana, K. Tomio, A. Yamashita, Y. Isobe, K. Nagasaka, K. Koga, T. Inoue, H. Nishida, S. Kojima, K. Adachi, Y. Matsumoto, T. Arimoto, O. Wada-Hiraike, K. Oda, J.X. Kang, H. Arai, M. Arita, Y. Osuga, T. Fujii
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Journal Title
PLoS One
Volume: 9
Pages: e89605
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[Journal Article] The prevalence of cervical regulatory T cells in HPV-related cervical intraepithelial neoplasia (CIN) correlates inversely with spontaneous regression of CIN2013
Author(s)
S. Kojima, K. Kawana, K. Tomio, A. Yamashita, A. Taguchi, S. Miura, K. Adachi, T. Nagamatsu, K. Nagasaka, Y. Matsumoto, T. Arimoto, K. Oda, O. Wada-Hiraike, T. Yano, Y. Taketani, T. Fujii, D.J. Schust, S. Kozuma
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Journal Title
Am J Reprod Immunol
Volume: 69
Pages: 134-141
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[Journal Article] The Prevalence Of Cervical Regulatory T Cells in HPV-Related Cervical Intraepithelial Neoplasia (CIN) Correlates Inversely with Spontaneous Regression of CIN2012
Author(s)
S. Kojima, K. Kawana, K. Tomio, A. Yamashita, A. Taguchi, S. Miura, K. Adachi, T. Nagamatsu, K. Nagasaka, Y. Matsumoto, T. Arimoto, K. Oda, O. Wada-Hiraike, T. Yano, Y. Taketani, T. Fujii, D.J. Schust, S. Kozuma
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Journal Title
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[Journal Article] Genotype-dependent efficacy of a dual PI3K/mTOR inhibitor, NVP-BEZ235, and an mTOR inhibitor, RAD001, in endometrial carcinomas2012
Author(s)
K. Shoji, K. Oda, T. Kashiyama, Y. Ikeda, S. Nakagawa, K. Sone, Y. Miyamoto, H. Hiraike, M. Tanikawa, A. Miyasaka, T. Koso, Y. Matsumoto, O. Wada-Hiraike, K. Kawana, H. Kuramoto, F. McCormick, H. Aburatani, T. Yano, S. Kozuma, Y. Taketani
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Journal Title
PLoS One
Volume: 7
Pages: e37431
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