ヒト卵巣におけるＦＯＸＬ２の機能解析

2012 Fiscal Year Annual Research Report

• Project/Area Number: 23791815
• Research Institution: The University of Tokyo
• Principal Investigator: 大石 元 東京大学, 医学部附属病院, 助教 (40401088)
• Keywords: 卵胞発育 / 性ステロイド合成 / FOXL2

Research Abstract

卵胞発育及び卵巣でのステロイド合成におけるFOXL2の役割を部分的に解明した。
卵巣顆粒膜細胞におけるFOXL2と抗加齢遺伝子SIRT1のアロマターゼ発現に対する協調効果を明らかにし、SIRT1の抑制因子であるDBC1とFOXL2の相互作用を明らかにした。
ヒト卵巣でのFOXL2の発現パターンを免疫染色で明らかにした。

Research Products

• [Journal Article] Spontaneous cessation and recurrence of massive uterine bleeding can occur in uterine artery (2013)
  • Author(s): Hajime Oishi
  • Journal Title: J Obstet Gynaecol Res. Volume: 39(2) Pages: 598-602
  • DOI: 10.1111/j.1447-0756.2012.01993.x. [Epub ahead of print]: 2012
  • Peer Reviewed
• [Journal Article] The human gonadotropin-inhibitory hormone ortholog RFamide-related peptide-3 suppresses gonadotropin-induced progesterone production in human granulosa cells (2012)
  • Author(s): Hajime Oishi
  • Journal Title: Endocrinology Volume: 153(7) Pages: 3435-3445
  • DOI: doi: 10.1210/en.2012-1066
  • Peer Reviewed
• [Journal Article] Regulation of SIRT1 determines initial step of endometrial receptivity by controlling E-cadherin expression (2012)
  • Author(s): Akira Shirane
  • Journal Title: Biochem Biophys Res Commun Volume: 424(3) Pages: 604-610
  • Peer Reviewed
• [Journal Article] Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells: an implicative role of SIRT1 in the ovary (2012)
  • Author(s): Y Morita
  • Journal Title: Reprod Biol Endocrinol. Volume: 23 Pages: 10-14
  • Peer Reviewed
• [Presentation] The effect of combined raloxifene and connjugated estrogen on bone metabolism, endometrial safety, and coagulation profile in postmenopausal osteoporotic women.
  • Author(s): Hajime Oishi
  • Organizer: ENDO2012
  • Place of Presentation: Houston, U.S.A.
• [Presentation] 不妊症患者における子宮内膜ポリープの治療とその効果に関する検討
  • Author(s): 大石 元
  • Organizer: 第57回日本生殖医学会学術講演会
  • Place of Presentation: 長崎