2012 Fiscal Year Final Research Report
Preeclampsia and autophagy- a new perspective for invasion failure of extravillous trophoblast
| Project/Area Number |
23791817
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | University of Toyama |
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Principal Investigator |
NAKASHIMA Akitoshi 富山大学, 大学院・医学薬学研究部(医学), 助教 (00436792)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 生殖医学 |
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| Research Abstract |
Soluble endoglin, which antagonizes vascularization, is elevated in serum in preeclamptic women. This study showed soluble endoglin inhibited hypoxia-induced autophagy in extravillous trophoblasts. Additionally, p62 protein, which is a selective protein degraded by autophagosome, accumulated in extravillous trophoblasts in placental bed biopsy samples of preeclampsia as well as autophagy-deficient EVT cell lines. Taken together, soluble endoglin-mediated autophagy inhibition in extravillous trophoblast was involved in pathophysiology of preeclampsia.
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[Journal Article] Impaired autophagy by soluble endoglin,under physiological hypoxia in early pregnant period, is involved in poor placentation in preeclampsia.2013
Author(s)
Nakashima A, Yamanaka-Tatematsu M, Fujita N, Koizumi K, Shima T, Yoshida T, Nikaido T, Okamoto A, Yoshimori T, Saito S
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Journal Title
Autophagy
Volume: 9
Pages: 303-316
Peer Reviewed
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