2012 Fiscal Year Final Research Report
The development of therapeutic target with system biological analysis of morphogen signals in ovarian cancer
| Project/Area Number |
23791834
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kyoto University |
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Principal Investigator |
YOSHIOKA Yumiko 京都大学, 大学院・医学研究科婦人科学産科学, 助教 (10402918)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 婦人科腫瘍学 |
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| Research Abstract |
We would like to identify the function of BMP/SMAD5 signaling in serous ovarian cancer. The protein levels of total SMAD5 and phosphorylated SMAD5 (pSMAD5) were examined by immunohistochemical analysis using clinical serous ovarian cancer samples. Cell proliferatio is promoted by BMP signaling,otherwise suppressed by inhibiting BMP signaling, bothin vitroand in vivo.Our data suggests that BMP/SMAD5 signaling plays an important role and, therefore, becomes a potential therapeutic target in serous ovarian cancer.
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