The development of therapeutic target with system biological analysis of morphogen signals in ovarian cancer

2012 Fiscal Year Final Research Report

• Project/Area Number: 23791834
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: Kyoto University
• Principal Investigator: YOSHIOKA Yumiko 京都大学, 大学院・医学研究科婦人科学産科学, 助教 (10402918)
• Project Period (FY): 2011 – 2012
• Keywords: 婦人科腫瘍学

Research Abstract

We would like to identify the function of BMP/SMAD5 signaling in serous ovarian cancer. The protein levels of total SMAD5 and phosphorylated SMAD5 (pSMAD5) were examined by immunohistochemical analysis using clinical serous ovarian cancer samples. Cell proliferatio is promoted by BMP signaling,otherwise suppressed by inhibiting BMP signaling, bothin vitroand in vivo.Our data suggests that BMP/SMAD5 signaling plays an important role and, therefore, becomes a potential therapeutic target in serous ovarian cancer.

Research Products

• [Journal Article] " Differential effects of inhibition of bone morphogenetic protein (BMP) signaling on T-cell activation and differentiation " (2012)
  • Author(s): Yumiko Yoshioka, Masahiro Ono, Motonao Osaki, Ikuo Konishi, Shimon Sakaguchi
  • Journal Title: European Journal of Immunology Volume: vol.42 Pages: 749-759
  • DOI: doi:10.1002/eji.201141702
  • Peer Reviewed
• [Presentation] The BMP signaling pathway leads to enhanced proliferation in serous ovarian cancer -A potential therapeutic target- (2012)
  • Author(s): Yumiko Yoshioka, Peng Jin
  • Organizer: 第10回アジア臨床腫瘍学会議
  • Place of Presentation: Seoul, Korea
  • Year and Date: 20120613-15
• [Presentation] The BMP signaling pathway leads to enhanced proliferation in serous ovarian cancer -A potential therapeutic target- (2012)
  • Author(s): Peng Jin, Yumiko Yoshioka
  • Organizer: 第64回日本産婦人科学会学術集会
  • Place of Presentation: 神戸国際展示場(兵庫県)
  • Year and Date: 20120413-15