2012 Fiscal Year Final Research Report
Investigation of aberrant metabolism in ovarian clear cell carcinoma using bioinformatics.
| Project/Area Number |
23791835
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 婦人科腫瘍学 |
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| Research Abstract |
It is known that ovarian clear cell carcinoma (CCC), arising in endometriotic cyst under reactive oxygen species (ROS) condition, exclusively expresses HNF1 β . In this study, we found HNF1 β confers ROS resistance in CCC cells. Furthermore, HNF1 β increased glucose uptake through upregulation of GLUT 1 expression. HNF1 β and its downstream genes were upregulated in CCC by hypomethylation.
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Research Products
(67 results)
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[Journal Article] Utilization of genomic signatures to identify high efficacy candidate drugs for chemo-refractory endometrial cancers.2013
Author(s)
Kharma B, Baba T, Mandai M, Matsumura N, Murphy SK, Kang HS, Yamanoi K, Hamanishi J, Yamaguchi K, Yoshioka Y, Konishi I.
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Journal Title
DOI
Peer Reviewed
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[Journal Article] Eph-ephrin A system regulates human choriocarcinoma-derived JEG-3 cell invasion.2013
Author(s)
Fujiwara H, Nishioka Y, Matsumoto H, Suginami K, Horie A, Tani H, Matsumura N, Baba T, Sato Y, Araki Y, Konishi I.
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Journal Title
Int J Gynecol Cancer.
Volume: 23(3)
Pages: 576-82.
DOI
Peer Reviewed
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[Journal Article] PD-L1 on tumor cells is induced in ascites andpromotes peritoneal dissemination of ovarian cancer through CTL dysfunction.2013
Author(s)
Abiko K, Mandai M, Hamanishi J, Yoshioka Y, Matsumura N, Baba T, Yamaguchi K, Murakami R, Yamamoto A, Kharma B, Kosaka K, Konishi I.
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Journal Title
Clin Cancer Res.
Volume: 19(6)
Pages: 1363-74.
DOI
Peer Reviewed
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[Journal Article] High-risk ovarian cancer based on 126-gene expression signature is uniquely characterized by down-regulation of antigen presentation pathway.2012
Author(s)
Yoshihara K, Tsunoda T, Shigemizu D, Fujiwara H, Hatae M, Fujiwara H, Masuzaki H, Katabuchi H, Kawakami Y, Okamoto A,Nogawa T, Matsumura N, Udagawa Y, Saito T, Itamochi H, Takano M, Miyagi E, Sudo T, Ushijima K, Iwase H, Seki H, Terao Y, Eno
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Journal Title
Clin Cancer Res.
Volume: 18(5)
Pages: 1374-85
DOI
Peer Reviewed
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[Journal Article] The activated transforming growth factor-beta signaling pathway in peritoneal metastases is a potential therapeutic target in ovarian cancer.2012
Author(s)
Yamamura S, Matsumura N, Mandai M, Huang Z, Oura T, Baba T, Hamanishi J, Yamaguchi K, Kang HS, Okamoto T, Abiko K, Mori S, Murphy SK, Konishi I.
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Journal Title
Int J Cancer.
Volume: 130(1)
Pages: 20-8
DOI
Peer Reviewed
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[Journal Article] GPR54 is a target for suppression of metastasis in endometrial cancer.2011
Author(s)
Kang HS, Baba T, Mandai M, Matsumura N, Hamanishi J, Kharma B, Kondoh E, Yoshioka Y, Oishi S, Fujii N, Murphy SK, Konishi I.
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Journal Title
Mol Cancer Ther.
Volume: 10(4)
Pages: 580-90
DOI
Peer Reviewed
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[Journal Article] Distinguishing primary from secondary mucinous ovarian tumors: an algorithm using the novel marker DPEP1.2011
Author(s)
Okamoto T, Matsumura N, Mandai M, Ora T, Yamanishi Y, Horiuchi A, Hamanishi J, Baba T, Koshiyama M, Shiozawa T, Konishi I.
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Journal Title
Mod Pathol.
Volume: 24(2)
Pages: 267-76
Peer Reviewed
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[Book] 産科と婦人科2012
Author(s)
万代昌紀、鈴木彩子、松村謙臣、馬場長、小西郁生.
Total Pages
267-273
Publisher
「子宮筋腫の発生メカニズムの最新知見は」
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