2012 Fiscal Year Final Research Report
Proliferation of uterine leiomyoma and the involvement of aberrant DNA methylation in estrogen receptor alpha target genes
| Project/Area Number |
23791846
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
MAEKAWA Ryo 山口大学, 医学部附属病院, 助教 (90598749)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 子宮筋 / DNA メチル化異常 / mRNA 発現異常 / estrogen receptor / progesterone receptor |
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| Research Abstract |
We investigated estrogen receptor alpha-target genes that showed aberrant DNA methylation and mRNA expression. As the results, we obtained four genes that showed hypomethylation and upregulation, one gene that showed hypomethylation and downregulation, six genes that showed hypermethylation and upregulation, and eleven genes that showed hypermethylation and downregulation. Because those genes included the genes involved in the tumor development and proliferation, those genes possibly contributes to the pathogenesis of uterine leiomyoma through aberrant DNA methylation.
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