2013 Fiscal Year Final Research Report
Characteristic changes of endothelial function in preeclampsia model rat by administration of nitric oxide synthase inhibitor
| Project/Area Number |
23791848
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Nagoya City University |
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Principal Investigator |
YAMAMOTO Tamao 名古屋市立大学, 医学(系)研究科(研究院), 研究員 (20405210)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 妊娠高血圧腎症 / 血管内皮機能障害 / 一酸化窒素 / 活性酸素 / 胎盤形成不全 |
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| Research Abstract |
Preeclampsia is characterized as an increased peripheral vascular resistance. It is found that administration of the NOS inhibitor L-NAME at early pregnancy developed hypertension in rat similar to preeclampsia. Furthermore, we found action of endothelial nitric oxide (NO) was reduced due to possibly reactive oxygen species (ROS) in preeclamptic women. We investigated whether this administration modulates NO and ROS production in uterine artery endothelial cells at late pregnancy in rat.
Blood pressure was higher and birth body weight was smaller in L-NAME-treated rats than in control rats. Trophoblast invasion was reduced in L-NAME-treated rats. ACh-induced endothelial NO production was higher, while endothelial cell ROS production and Ca increase was similar, in L-NAME-treated rats when compared with those in control rats. It is suggested that the increased endothelial NO production in uterine artery seen in L-NAME-treated rats may function to protect the development of hypertension.
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Research Products
(18 results)
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[Journal Article] Committee report on cerebrovascular disorders, including eclampsia and emergency medical services, of the Japan Society for the Study of Hypertension in Pregnancy2013
Author(s)
Suzuki Y, Adachi T, Ohno Y, Matsuda H, Naruse K, Metoki H, Nakai Y, Nakamoto O, Watanabe K, Ohkuchi A, Yamamoto T
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Journal Title
Hypertens Res Pregnancy
Volume: 1
Pages: 8-12
DOI
Peer Reviewed
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