Development of a new immunotherapy for ovarian cancer by utilizing the cytotoxic effects and adjuvant properties of natural killer T cells

2012 Fiscal Year Final Research Report

• Project/Area Number: 23791850
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: Saitama Medical University
• Principal Investigator: SUZUKI Motoharu 埼玉医科大学, 医学部, 講師 (50406443)
• Project Period (FY): 2011 – 2012
• Keywords: 婦人科腫瘍学 / 卵巣がん / 樹状細胞 / NKT細胞

Research Abstract

The present study investigated the role of human iNKT cells in the regulation of Osteopontin (OPN)production by dendritic cells (DCs). The activation of iNKT cells by their specific ligand α-galactosylceramide inhibitsthe OPN production byDCs. The downregulation of OPN is associated with a production of IL-4, IL-13, and IFN-γfrom iNKT cells. These findings indicate that iNKT cells modify the DC functionto suppress the OPN-dependent inflammatory condition that promotes the tumor development

Research Products

• [Journal Article] 子宮収縮薬の使い方診断と治療社「産科と婦人科」 (2012)
  • Author(s): 鈴木元晴, 板倉敦夫
  • Journal Title: 産科と婦人科 Volume: 5(33) Pages: 561-566
• [Journal Article] リコンビナントFSHの基礎 (2012)
  • Author(s): 石原理, 鈴木元晴, 菊地真理子, 梶原健, 岡垣竜吾
  • Journal Title: 産科と婦人科 Volume: 79(7) Pages: 854-858
• [Journal Article] 器械的熟化併用による分娩誘発の成績-分娩誘発177症例の後方視的検討 (2012)
  • Author(s): 大塚純一, 岡垣竜吾, 中山真人, 鈴木 裕之, 鈴木元晴, 石原理, 荒木隆一郎, 板倉敦夫
  • Journal Title: 日本産科婦人科学会関東連合地方部会誌 Volume: 49(4) Pages: 495-502
• [Journal Article] Human chorionic gonadotropin confers resistance to oxidative stress-induced apoptosis in decidualizing human endometrial stromal cells. (2011)
  • Author(s): Kajihara, T., Uchino, S., Suzuki, M., Itakura, A., Brosens, J.J., Ishihara, O.
  • Journal Title: Fertil. Steril. Volume: 95 Pages: 1302-1307
  • Peer Reviewed
• [Presentation] Regulation of IL-27/Osteopontin balance in dendritic cells by ligand activation of invariant NKT cells. (2012)
  • Author(s): Rong Zhang, Tianyi Liu, Motoharu Suzuki, Narumi Hirosawa, Shin Kaneko, Ayako Okamura, Yasushi Sakamoto, Kiyotaka Kuzushima, and Yasushi Uemura
  • Organizer: 第41回日本免疫学会学術集会(神戸市)
  • Year and Date: 20121205-07
• [Presentation] Modification of IL-12p70/Osteopontin balance in dendritic cells by ligand activation of invariant NKT cells. (2012)
  • Author(s): Motoharu Suzuki, Tianyi Liu, Narumi Hirosawa, Yayoi Nobori, Ayako Okamura, Yasushi Sakamoto, Kiyotaka Kuzushima, and Yasushi Uemura.
  • Organizer: 第71回日本癌学会学術総会(札幌市)
  • Year and Date: 20120919-21