2013 Fiscal Year Final Research Report
Micro RNA analysis in orooraryngeal carcinoma
| Project/Area Number |
23791867
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 頭頸部癌 / 中咽頭癌 / ＨＰＶ |
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| Research Abstract |
We performed a retrospective analysis of the association between tumour HPV status and the demographic and clinicopathological parameters of 71 patients with oropharyngeal squamous cell carcinoma. Of the 71 patients, 23 were HPV-positive. Kaplan-Meier survival analysis showed improved overall survival rates in patients with HPV-positive tumours compared with HPV-negative tumours. Of the 45 patients received chemoradiotherapy, HPV-positive patients experienced better overall survival than HPV-negative patients. We performed a retrospective analysis of the association between p16 expression and HPV status. Of the 91 patients, 29 were HPV-positive and 31 were p16-positive. The 3-year overall survival rates were 82.2% in the p16-positive subgroup and 65.1% in the p16-negative subgroup. Our results showed that the patients with HPV-/p16+ had poor prognosis as compared with the patients with HPV+/p16+, therefore p16 IHC alone may not be a perfect surrogate marker for HPV infection.
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[Journal Article] Regional control after concomitant chemoradiotherapy without planned neck dissection in node-positive head and neck squamous cell carcinomas2013
Author(s)
Sakashita T, Homma A, Oridate N, Suzuki S, Hatakeyama H, Kano S, Mizumachi T, Onimaru R, Tsuchiya K, Yasuda K, Shirato H, Fukuda S
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Journal Title
Auris Nasus Larynx
Volume: 40
Pages: 211-5
Peer Reviewed
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[Journal Article] Combined modality therapy for laryngeal cancer with superselective intra-arterial cisplatin infusion and concomitant radiotherapy2012
Author(s)
Taki S, Homma A, Suzuki F, Oridate N, Hatakeyama H, Mizumachi T, Kano S, Furusawa J, Sakashita T, Inamura N, Yoshida D, Onimaru R, Shirato H, Fukuda S
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Journal Title
Int J Clin Oncol
Volume: 17
Pages: 441-6
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[Journal Article] 切除可能T3、T4上顎洞扁平上皮癌における手術の位置付け. 当院における治療戦略2012
Author(s)
本間明宏,折舘伸彦,鈴木清護,鈴木章之,畠山博充,加納里志,水町貴諭,坂下智博,吉田大介,鬼丸力也,土屋和彦,安田耕一,白土博樹,福田諭
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Journal Title
耳鼻と臨床
Volume: 58
Pages: 52-56
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[Journal Article] 頭頸部癌化学放射線療法における経管栄養の役割に関する検討2012
Author(s)
倉本倫之介,折舘伸彦,本間明宏,及川敬太,藤田香,鈴木清護,畠山博充,加納里志,水町貴諭,坂下智博,福田諭
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Journal Title
嚥下医学
Volume: 1
Pages: 359-63
Peer Reviewed
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[Journal Article] Concomitant weekly cisplatin and radiotherapy for head and neck cancer2011
Author(s)
Homma A, Inamura N, Oridate N, Suzuki S, Hatakeyama H, Mizumachi T, Kano S, Sakashita T, Onimaru R, Yasuda K, Shirato H, Fukuda S
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Journal Title
Jpn J Clin Oncol
Volume: 41
Pages: 980-6
Peer Reviewed
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[Journal Article] Superselective arterial cisplatin infusion with concomitant radiation therapy for base of tongue cancer2011
Author(s)
Kano S, Homma A, Oridate N, Suzuki F, Hatakeyama H, Mizumachi T, Furusawa J, Sakashita T, Yoshida D, Onimaru R, Shirato H, Fukuda S
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Journal Title
Oral Oncol
Volume: 47
Pages: 665-70
Peer Reviewed
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[Journal Article] 顎下腺悪性腫瘍1次症例の検討2011
Author(s)
北尾恭子,本間明宏,折舘伸彦,鈴木清護,鈴木章之,原敏浩,加納里志,水町貴諭,瀧重成,稲村直哉,福田諭
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Journal Title
日本耳鼻咽喉科学会会報
Volume: 114
Pages: 126-32
Peer Reviewed
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