2012 Fiscal Year Final Research Report
Expression of the MicroRNAs in Nasal Natural Killer/T-Cell Lymphoma
| Project/Area Number |
23791868
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Otorhinolaryngology
|
|---|
| Research Institution | Asahikawa Medical College |
|---|
Principal Investigator |
KISHIBE Kan 旭川医科大学, 医学部, 助教 (80447101)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | 鼻性NK/T細胞リンパ腫 / Epstein-Barr virus / マイクロRNA / mir-15a |
|---|
| Research Abstract |
We found that microRNA (miR)-15a was expressed at a much lower level in Nasal NK/T cell lymphoma (NNKTL) cells than in normal peripheral NK-cells and EBV-negative NK-cell line KHYG-1. In NNKTL, down-regulation of miR-15a possibly due to LMP1 implicates in the pathogenesis of NNKTL through cell proliferation via enhancing expressions of the targeting MYB and cyclin D1.
|
Research Products
(11 results)
