2012 Fiscal Year Final Research Report
Investigation of a novel prognostic marker in head and neck squamous cell carcinoma
| Project/Area Number |
23791875
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Teikyo University (2012)
Chiba University (2011) |
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Principal Investigator |
KATADA Koji 帝京大学, 医学部, 助教 (60596112)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 頭頸部癌 / プロテオミクス / 予後マーカー |
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| Research Abstract |
We identified plectin as a promising prognostic biomarker in head and neck squamous cell carcinoma (HNSCC) using proteomic technics and functional studies implied that a decreased expression of plectin suppresses the proliferation,migration and invasion of HNSCC cells. Furthermore, the survival rate of patients with high plectin was significantly lower than that of patients with low E-cadherin levels, which is known to correlate with the poor prognosis of HNSCC.
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