2012 Fiscal Year Final Research Report
Analysis for structural-functional interaction of a mammalian candidate sour taste receptor, PKD1L3/PKD2L1 complex
| Project/Area Number |
23791881
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 咽頭科学 |
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| Research Abstract |
In the present study, we analyzed structural-functional interaction of a mammalian candidate sour taste receptor, PKD1L3/PKD2L1 complex. We aimed to identify the molecular determinants responsible for the Ca2+ permeability of the PKD1L3/PKD2L1 complex. By Ca2+ imaging analyses, we demonstrated that the single pore residue Asp523 in PKD2L1 determines Ca2+ permeation of the PKD1L3/PKD2L1 complex.
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Research Products
(15 results)
