2012 Fiscal Year Final Research Report
Differential diagnosis of thyroid tumor by cleaved galectin-3
| Project/Area Number |
23791893
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 甲状腺癌 |
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| Research Abstract |
We performed immunohistochemistry of surgical specimens of thyroid cancer with antibody against intact galectin-3 and antibody against cleaved galectin-3. Intact galectin-3 was diffusely expressed in any thyroid papillary cancer specimens. In contrast, galectin-3 expression in follicular cancer specimens varied depending on the specimens. Immunohistochemistry with anti-cleaved galectin-3 antibody have been unsuccessful so far, and we are now working on it. Also, we are working on the establishment of cleaved galectin-3 detection system with ELISA. With respect to clinical study, we are investigating the association between galectin-3 expression and prognosis of follicular cancer.
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Research Products
(1 results)
