2012 Fiscal Year Final Research Report
Investigating the mechanism of diabetes associated hearing impairment by aging.
| Project/Area Number |
23791896
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Otorhinolaryngology
|
|---|
| Research Institution | Kobe University |
|---|
Principal Investigator |
FUJITA Takeshi 神戸大学, 医学研究科, 医学研究員 (90533711)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | 糖尿病 / 音響外傷 / 難聴 / 内耳 |
|---|
| Research Abstract |
We aimed to investigate the pathophysiology of diabetes- associated hearing impairment in type1 diabetes using mice with diabetes. Chronologic changes in the ABR threshold shift were not significantly different between the diabetic and control groups. However, vessel walls in the modiolus of the cochleae were significantly thicker inthe diabetic group than the control group. Additionally, recovery from noise-induced injury was significantly impaired in diabetic mice. Our data suggest that diabetic cochleae are more susceptible than controls to loud noise exposure.
|
