2012 Fiscal Year Final Research Report
The central role of CD30L/CD30 interactions in allergic rhinitis pathogenesis in mice
| Project/Area Number |
23791899
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Shimane University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | CD30 ligand / allergic rhinitis / Th2 cells / CD30 Ig fusion protein |
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| Research Abstract |
CD30L/CD30 signaling is more important in the secondary response at the allergic inflammatory site rather than during the initial phase of antigen priming in the LNs and spleen. The suppression of CD30L/CD30 signaling by soluble CD30-Ig fusion protein can suppress or regulate rhinitis development and might be useful for the therapy of allergic rhinitis.
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