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2013 Fiscal Year Final Research Report

Innovative regenerative medicine of hearing loss after cochlear ischemia by embryonic stem cells

Research Project

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Project/Area Number 23791903
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionEhime University

Principal Investigator

TAKAGI Taro  愛媛大学, 医学部附属病院, 医員 (20601024)

Project Period (FY) 2011 – 2013
Keywords内耳再生 / ES細胞 / 突発性難聴
Research Abstract

We investigated the influence of HSCs on progressive hair cell degeneration after transient cochlear ischemia in gerbils. Transient cochlear ischemia was produced by extracranial occlusion of the bilateral vertebral arteries. HSCs were administrated via femoral vein. Transplanted cells were confirmed in the spiral modiolar artery but was not found in the organ of Corti. Sequential changes in hearing were assessed by ABR. HSCs group was significantly decreased ABR threshold shift compared to the control group. The average ratio of dead/intact cells of inner hair cells was significantly smaller in the HSCs group than control group. The increasing of trophic factors protein level in the organ of Corti in the HSCs group indicated that HSCs upregulated the trophic factors. The intravenous injected HSCs could prevent hair cell degeneration and ameliorate hearing impairment. These results suggested that HSCs had therapeutic potential possibly through paracrine effects.

  • Research Products

    (2 results)

All 2013

All Presentation (2 results)

  • [Presentation] Hematopoietic stem cells prevent hair cell death after transient cochlear ischemia2013

    • Author(s)
      Taro Takagi, Tadashi yoshida, Nobuhiro Hakuba, Naohito Hato, Kiyofumi Gyo
    • Organizer
      29^<th> Politzer society meeting
    • Place of Presentation
      Susesi Resort(Antalya, Turkey)
    • Year and Date
      20131114-17
  • [Presentation] 虚血性内耳障害に対する造血幹細胞静脈内投与の効果2013

    • Author(s)
      高木太郎、吉田正、白馬伸洋、暁清文
    • Organizer
      第58回日本聴覚医学会
    • Place of Presentation
      ホテルブエナビスタ(長野県松本市)
    • Year and Date
      20131024-25

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Published: 2015-06-25  

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