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2013 Fiscal Year Final Research Report

Analysis of new oral immunotherapy with Cry j1-galactomannan conjugate for Japanese cedar pollinosis

Research Project

  • PDF
Project/Area Number 23791905
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionKyushu University

Principal Investigator

MURAKAMI Daisuke  九州大学, 大学病院, その他 (80568965)

Project Period (FY) 2011 – 2013
Keywordsスギ花粉症 / 経口免疫療法 / スギ抗原-ガラクトマンナン複合体 / 経口免疫寛容
Research Abstract

In this study, we assessed for the first time the safety and efficacy of a new short-term oral immunotherapy (OIT) for Japanese cedar pollinosis using the Cry j1-galactomannan conjugates, which could include high-dose allergens and could be decreased the risk of anaphylaxis. Participants receiving OIT for about two months from a month before the pollen season showed significant improvements in rhinoconjunctivitis and medication use through the pollen season and furthermore the next pollen season without OIT compared with control group. Importantly, no side effects such as life-threatening were observed in participants receiving OIT.
These results suggest that a new short-term OIT using allergen-galactomannan conjugates may provide a rapid, convenient, effective, and safe immunotherapy regimen for Japanese cedar pollinosis.

  • Research Products

    (4 results)

All 2014 2013 2012 2011

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (3 results)

  • [Journal Article] Phase I/II study of oral immunotherapy with Cry j1–galactomannan conjugate for Japanese cedar pollinosis2014

    • Author(s)
      Daisuke Murakami, et al
    • Journal Title

      ANL

      Volume: 41 Pages: 350–358

    • Peer Reviewed
  • [Presentation]2013

    • Organizer
      第52回日本鼻科学会総会・学術講演会
    • Year and Date
      20130000
  • [Presentation]2012

    • Organizer
      第30回日本耳鼻咽喉科免疫アレルギー学会
    • Year and Date
      20120000
  • [Presentation]2011

    • Organizer
      第50回日本鼻科学会総会・学術講演会
    • Year and Date
      20110000

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Published: 2015-06-25  

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