Pathogenesis of spasmodic dysphonia using functional brain imaging

2014 Fiscal Year Final Research Report

• Project/Area Number: 23791913
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: University of the Ryukyus
• Principal Investigator: KIYUNA ASANORI 琉球大学, 医学(系)研究科(研究院), 助教 (10433103)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: 痙攣性発声障害 / 脳機能画像 / fMRI

Outline of Final Research Achievements

Spasmodic dysphonia (SD) is a disease that lead to a strained/strangled, hoarse, and effortful voice and is increasing in recent years. It is considered that it is caused by the abnormality of the brain function although the pathophysiology of SD is unknown enough. We carried out functional magnetic resonance imaging (fMRI) for patients with SD and assessed their brain function. It showed dysfunctions of the basal ganglia and the parietal association area, which integrated a sense, by comparing the various vocalization tasks, and brain activities before and after surgery (type 2 thyroplasty).It was suggested the possibility that these areas were associated with the onset of the SD deeply.

Free Research Field

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