Functional analysis and differentiation induction of antigen presenting cells via DDS in human nasal epithelial cells

2012 Fiscal Year Final Research Report

• Project/Area Number: 23791915
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Sapporo Medical University
• Principal Investigator: GO Mitsuru 札幌医科大学, 医学部, 講師 (80448604)
• Project Period (FY): 2011 – 2012
• Keywords: 咽頭科学

Research Abstract

Nasopharynx and nasal mucosa are located at the forefront of the host defense against foreign pathogens, which plays an important role in acquired immunityand innate immunity. To elucidate the immune system of allergy infection, we analyzed the mechanism of epithelial barrier function and antigen presentation in the nasalepithelium of human nasopharyngeal epithelium.

Research Products

• [Journal Article] Regulation of tight junctions in upper airway epithelium. (2013)
  • Author(s): Kojima T, Go M, Takano K, Kurose M, Ohkuni T, Koizumi J, Kamekura R, Ogasawara N, Masaki T, Fuchimoto J, Obata K, Hirakawa S, Nomura K, Keira T, Miyata R, Fujii N, Tsutsumi H, Himi T, Sawada N.
  • Journal Title: Biomed Res Int
  • Peer Reviewed
• [Journal Article] Mucosal immune barrier and antigen-presenting system in human nasal epithelial cells (2011)
  • Author(s): Himi T, Takano K, Ogasawara N, Go M, Kurose M, Koizumi J, Kamekura R, Kondo A, Ohkuni T, Masaki T, Kojima T, Sawada N, Tsutsumi H
  • Journal Title: Adv Otorhinolaryngol. Volume: 72 Pages: 28-30
  • Peer Reviewed