2013 Fiscal Year Final Research Report
Development of a Hybrid Three-Dimensional Culture Method in Regenerative Medicine
| Project/Area Number |
23791917
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI Masahiro 福島県立医科大学, 医学部, 助手 (90513268)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 移植 / 再生医療 |
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| Research Abstract |
Adipose Derived Stem Cells (ASC) and fibroblasts each promote the regeneration of the tracheal epithelial layer. In this study, we created a 3D Architecture of cell layered arrangement (3D-A) in order to simultaneously make use of the strong points of ASC and fibroblasts. Upon grafting of 3D-A into the tracheal injury model of a rat, we were able to confirm the regeneration of a functional tracheal epithelial layer to near its normal morphology in a shorter time than with grafting of ASC or fibroblasts alone. The development of this hybrid 3D culture method seems to be capable of contributing greatly to trachea regenerative medicine.
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