An association between refractory rhinosinusitis and lower respiratory tract disease

2014 Fiscal Year Final Research Report

• Project/Area Number: 23791943
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Jikei University School of Medicine
• Principal Investigator: WADA Kota 東京慈恵会医科大学, 医学部, 講師 (20307482)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: 副鼻腔 / 好酸球 / 副鼻腔炎 / 好酸球性副鼻腔炎 / IL-33 / Alternaria

Outline of Final Research Achievements

We performed hematoxylin and eosin stain using the tissue which we obtained and observed degree of the eosinophil leukocytic infiltrate, an epithelial cells and performed immunostaining for IL -33. It showed eosinophil infiltrate in the atopic type bronchial asthma patients, the non-atopic type bronchial asthma patients, the patients with aspirin asthma strongly. The staining of IL -33 tended to be stained by epithelium. We tended to be stained in patients with eosinophilic rhinosinusitis, but the significant difference was absent. We cultured fibroblasts from a nasal polyp, and Alternaria stimulation showed the production of IL-6. However, the production of IL -33 from fibroblasts was absent. We cultured epithelial cells derived from nose and sinus mucosa and we established culture system, but were not able to do it about the state of the production of IL -33, the genetic expression.

Free Research Field

耳鼻咽喉科