2012 Fiscal Year Final Research Report
The development of a new therapy for diabetic retinopathy targeting the receptor-associated prorenin system
| Project/Area Number |
23791955
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 受容体随伴プロレニン系 / 糖尿病網膜症 |
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| Research Abstract |
The present study for the first time demonstrated that reactive oxygen species derived from ischemia-reperfusion injury didn't activate the receptor-associated prorenin system in the retina. Moreover, the statistical analysis using the data form the patients with or without diabetes clearly demonstrated that the higher HbA1c and blood pressure were largely associated with the prorenin concentration in the blood. A further experiment is still being carried out using extracted porcine retinal arteriole in order to determine the role of prorenin in the regulation of retinal circulation.
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[Presentation] 非糖尿病患者における血中プロレニン値に関係する因子
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[Presentation] The serum levels of prorenin in Non-Diabetic Subjects
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[Presentation] 分散ヘスペレチンは虚血性網膜症の神経節細胞死を抑制する
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[Presentation] Water-dispersible hespertin prevents ganglion cell loss in the retinal ischemia reperfusion injury
