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2013 Fiscal Year Final Research Report

The role of mu-crystallin in laser-induced choroidal neovascularization

Research Project

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Project/Area Number 23791973
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Ophthalmology
Research InstitutionShinshu University

Principal Investigator

IMAI Hiroki  信州大学, 医学部, 助教 (50568409)

Project Period (FY) 2011 – 2013
Keywordsミュークリスタリン / 脈絡膜新生血管
Research Abstract

Choroidal neovascularization model was induced by laser photocoagulation(125 micrometer spot size, 130mW intensity, 50ms duration; 80nm; Oculight SLx; Iris Instruments, Mountain View, CA) performed on one eye of male C57BL6, mu-crystallin knockout, and wild-type mice (8 to 12 weeks of ages)choroid-sclera flatmount was stained by anti-isolectin antibody. The volume and area of neovascularization were measured by laser confocal microscopy (TCS SP2; Leica). The mean volume or area of choroidal neovascularization was not significantly different from mu-crystallin knockout mice and wild-type mice.

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Published: 2015-06-25  

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