2013 Fiscal Year Final Research Report
The role of mu-crystallin in laser-induced choroidal neovascularization
| Project/Area Number |
23791973
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Shinshu University |
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Principal Investigator |
IMAI Hiroki 信州大学, 医学部, 助教 (50568409)
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| Project Period (FY) |
2011 – 2013
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| Keywords | ミュークリスタリン / 脈絡膜新生血管 |
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| Research Abstract |
Choroidal neovascularization model was induced by laser photocoagulation(125 micrometer spot size, 130mW intensity, 50ms duration; 80nm; Oculight SLx; Iris Instruments, Mountain View, CA) performed on one eye of male C57BL6, mu-crystallin knockout, and wild-type mice (8 to 12 weeks of ages)choroid-sclera flatmount was stained by anti-isolectin antibody. The volume and area of neovascularization were measured by laser confocal microscopy (TCS SP2; Leica). The mean volume or area of choroidal neovascularization was not significantly different from mu-crystallin knockout mice and wild-type mice.
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