2012 Fiscal Year Final Research Report
Analysis on roles of immune modulating cytokines for strategic development of molecular therapeutics for age-related macular degeneration
| Project/Area Number |
23791984
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Tottori University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 加齢黄斑変性 |
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| Research Abstract |
We analyzed the relationship between the levels of intraocular inflammatory cytokines and polypoidal choroidal vasculopathy (PCV), a major form of age related macular degeneration (ARMD), and found a significantly high risk was provided by elevation of IL-23, VEGF, and IL-4. To further understand molecular pathology of choroidal neovascularization (CNV), we also analyzed cytokine levels of myopic CNV patients. IL-10 provided a significantly high risk for myopic CNV. To understand inflammatory aspect of CNV, murine laser induced choroidal neovascularization model was used. Currently, our analysis on the mouse CNV model has identified the candidate target signaling molecule for ARMD using analysis of transgenic mouse strains for signaling of the molecule
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Research Products
(5 results)
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[Journal Article] Assessment of real-time polymerase chain reaction detection of acanthamoeba and prognosis determinants of acanthamoeba keratitis2012
Author(s)
Ikeda Y, Miyazaki D, Yakura K,Kawaguchi A, Ishikura R, Inoue Y, Mito T, Shiraishi A, Ohashi Y, Higaki S, Itahashi M, Fukuda M, Shimomura Y, Yagita K
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Journal Title
Ophthalmology
Volume: 119
Pages: 1111-1119
Peer Reviewed
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