2012 Fiscal Year Final Research Report
The neuroprotection for photoreceptor apoptosis via selective antagonist, BBG
| Project/Area Number |
23791991
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | 国立病院機構九州医療センター (2012)
National Hospital Organization, Kyushu Medical Center (Clinical Institute) (2011) |
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Principal Investigator |
HISATOMI Toshio 国立病院機構九州医療センター, 眼科, 科長 (50404033)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 眼細胞生物学 |
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| Research Abstract |
The retinal cells developed apoptosis via P2X7 receptor dependent pathways. Cell death developed via rapid Ca++ intake into the cells and followed by apoptotic molecular signals such as membrane permeabilization, caspase activation, cytochrome c and AIF translocation. P2X7 receptor knockout mice showed decreased cell death without P2X7 receptor. The cell death and following molecular signal transduction were reversed by selective antagonist, BBG.
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