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2012 Fiscal Year Final Research Report

Novel administration of anti-VEGF antibody for retinopathy of prematurity

Research Project

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Project/Area Number 23792006
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Ophthalmology
Research InstitutionShowa University

Principal Investigator

SAITO Yuta  昭和大学, 医学部, 助教 (70407477)

Project Period (FY) 2011 – 2012
Keywords薬理学 / 未熟児網膜症 / 血管内皮増殖因子 / 抗VEGF抗体 / 薬物動態
Research Abstract

We investigated that the effect, pharmacokinetics and toxicity of subconjunctival or intravitreal injections of anti-VEGF antibody for OIR rat model. Subconjunctival injection of anti-VEGF suppressed the retinal neovascularization in OIR rat model; even the effect was smaller than that of intravitreal injection. The antibody escapedinto systemic circulation, thus it affected fellow eyes. The toxicity for retinas was not detected.

  • Research Products

    (3 results)

All 2012 2011

All Journal Article (1 results) Presentation (2 results)

  • [Journal Article] Effects of Subconjunctival Injection of Anti-Vascular Endothelial Growth Factor Antibody on Oxygen-Induced Ischemic Retinopathy in a Neonatal Rat Model2012

    • Author(s)
      Kabayama J, Saito Y, Nakanishi-Ueda T, Ueda T, Matsubara M, Wada Y, Okawada H, Hisamitsu T, Koide R
    • Journal Title

      The Showa University Journal of Medical Sciences

      Volume: 24(1) Pages: 11-9

  • [Presentation] 高濃度酸素負荷虚血網膜症ラットに対する抗VEGF抗体結膜下投与の効果の検討2011

    • Author(s)
      蒲山順吉、齋藤雄太、植田俊彦、中西孝子、松原 倫子、和田悦洋、久光正、小出良平
    • Organizer
      第31回日本眼薬理学会
    • Place of Presentation
      島根県松江市
    • Year and Date
      20110917-18
  • [Presentation] Effects of Subconjunctival Injection of anti-VEGF Antibody on Oxygen-induced Retinal Neovascularization of the Neonatal Rat Model2011

    • Author(s)
      Yuta Saito, Takako Nakanishi-Ueda, Toshihiko Ueda, Yoshihiro Wada, Hajime Yasuhara, Ryohei Koide
    • Organizer
      ARVO 2011 Annual Meeting
    • Place of Presentation
      Fort Lauderdale
    • Year and Date
      20110501-05

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Published: 2014-09-25  

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