2013 Fiscal Year Final Research Report
Immunological analysis of glaucoma patients
| Project/Area Number |
23792008
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 液性因子 / サイトカイン / ケモカイン / 増殖因子 / MCP-1 / 線維柱帯切除術 / 後嚢化白内障 / 緑内障 |
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| Research Abstract |
Undiluted aqueous humor samples of primary open-angle glaucoma (POAG) patients were collected at the start of trabeculectomy, and cytometric beads array kits were used to determine the concentrations of immune mediators. The correlation of aqueous humor concentration of each immune mediator with pre and post-operative clinical factors were analyzed.
A significant relationship between incidence of posterior capsular cataract and MCP-1 level was detected.
Our study suggests that elevated MCP-1 level in aqueous humor in patients with POAG undergoing trabeculectomy affects the incidence of postoperative posterior capsular cataract.
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