2012 Fiscal Year Final Research Report
The role of aquaporin in the mechanism of adipocyte graft survival
| Project/Area Number |
23792036
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Plastic surgery
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| Research Institution | Chiba University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 組織培養 / 移植学 |
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| Research Abstract |
Aquaporin1, first discovered as a water channel, is suggested to have multiple roles including cell migration. We previously reported that hypoxia increased Aquaporin1 in human retinal vascular endothelial cell. In this study, we have revealed that both adipose derived stem cell and ceiling culture derived proliferative adipocyte, harvested from human abdominal subcutaneous fat tissue, have Aquaporin 1. Hypoxia increases Aquaporin 1 in both types of cell. The result suggests that aquaporin 1 is related to not only a water transportation but also cell survival in hypoxic condition.
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