2012 Fiscal Year Final Research Report
A genome-wide association study for keloid disease and functional analysis of keloid candidate genes
| Project/Area Number |
23792040
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Plastic surgery
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| Research Institution | Yokohama City University (2012)
The University of Tokyo (2011) |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | GWAS / non-coding RNA / マイクロアレイ / Wnt signaling |
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| Research Abstract |
We carried out multi-stage genome-wide association study and identified four susceptible loci to keloid. Among the four loci, we identified the new long non-coding RNA genes in one locus. These genes showed higher expression in keloid tissues than normal skin tissues and contributed to accelerate the fibroblast cell proliferation. Microarray analysisrevealed these genes involved in keloid formation through Wnt signaling pathway
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