2012 Fiscal Year Final Research Report
The role of Rho/Rho kinase in wound healing
| Project/Area Number |
23792043
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Plastic surgery
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 創傷治癒学 |
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| Research Abstract |
Rho kinse-inhibited cells increased the migration rate as compared to the control cells in the wound healing assay. Moreover, Rho kinase-inhibited cells showed activation of cofilinin western blotting. Inhibition of Rho kinase promoted cell migration and wound healing in DM model mouse. These data showed that inhibition of Rho kinase have positive effects in wound healing.
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