2013 Fiscal Year Final Research Report
Primary bone graft for cleft lip and palate using umbilical cord-derived mesenchymal stem cells
| Project/Area Number |
23792049
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Plastic surgery
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 臍帯由来間葉系幹細胞 / 口唇口蓋裂 |
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| Research Abstract |
Prenatal diagnosis of cleft lip and palate is accurate. We investigated the clinical applicability of umbilical cord-derived mesenchymal stem cells harvested at birth for primary gingivoperiosteoplasty and bone grafting 3 to 6 months after birth. Secondary bone grafting, which is usually performed when the patient is 5 to 10 years old using iliac cancellous bone, provides good results.
Our findings revealed that the quality of umbilical cord-derived mesenchymal stem cells differed from that of iliac cancellous bone-derived mesenchymal stem cells, because differentiation of umbilical cord-derived mesenchymal stem cells into bone cells was difficult to achieve. We detected no difference between the bone formations in the umbilical cord-derived mesenchymal stem cell graft model and those of the non-cell graft model using the nude mouse with partial maxillary defects. Studies of the recipient niche might be as important as the cell quality.
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