2012 Fiscal Year Final Research Report
An investigation of regulatory T cell (Treg) in systemic inflammaotory response syndrome
| Project/Area Number |
23792069
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Emergency medicine
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 細胞性免疫 / 制御性 T 細胞 / 多臓器不全 |
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| Research Abstract |
The idea of systemic inflammatory response syndrome (SIRS) is proposed by the society of critical care medicine in 1992. SIRS is an acute inflammatory response caused by serious disease like trauma, sepsis and burn. Hyperthermia, tachycardia, tachypnea and increased leucocyte are observed in SIRS.
It is known that massive quantity cytokine induced from immune cell causes SIRS. We investigated the function of regulatory T cell (Treg) which suppresses immunological response.
We found that the number of Treg was increased in critically-ill patients which is especially sensitive to infection.Therefore, it might be that the evaluation and regulation of Treg result in a key to a better treatment of sepsis and infection.
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[Journal Article] Dramatic changes of the gut flora immediately after severe and sudden insults2012
Author(s)
Hayakawa M, Asahara T, Henzan N, Murakami H, Yamamoto H, Mukai N, Minami Y, Sugano, M, Kubota N, Uegaki S, Kamoshida H, Sawamura A, Nomoto K, Gando S
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Journal Title
Digestive Diseases and Sciences
Volume: 56巻
Pages: 2361-2365
DOI
Peer Reviewed
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