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2013 Fiscal Year Final Research Report

Effect of autophagy-related polymorphism on inflammatory reaction of severe SIRS

Research Project

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Project/Area Number 23792070
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Emergency medicine
Research InstitutionTokyo Women's Medical University (2013)
Chiba University (2011-2012)

Principal Investigator

KIMURA TOMONORI  東京女子医科大学, 医学部, 医療練士研修生 (90598236)

Research Collaborator WATANABE Eizo  千葉大学, 大学院医学研究科, 准教授 (40375639)
ODA Shigeto  千葉大学, 大学院医学研究科, 教授 (90204205)
Project Period (FY) 2011 – 2013
Keywords重症敗血症 / オートファジー / 遺伝子多型
Research Abstract

We examined the association between autophagy-related IRGM (human immunity-related GTPase) polymorphism and clinical course/outcome in patients with severe sepsis. We have set the 2 cohorts and lipopolysaccharide challenge of whole blood from randomly selected healthy volunteers was performed for comparison of IRGM mRNA expression among different genotypes. When mortality were compared, no significant difference was observed in the non-sepsis group, while TT homozygotes exhibited a significantly higher mortality than that of the CC+CT genotype category in the severe sepsis group for both cohorts. Lipopolysaccharide challenge showed a significant suppression of IRGM mRNA expression in TT homozygotes compared with that of the CC+CT genotype category. The data suggest that IRGM(+313) SNP, an autophagy-related polymorphic locus, influences outcome in patients with severe sepsis, with the possible involvement of autophagy in sepsis exacerbation.

  • Research Products

    (7 results)

All 2014 2013 2012

All Journal Article (2 results) Presentation (5 results)

  • [Journal Article] Autophagy-Related IRGM polymorphism is associated with mortality of patients with severe sepsis2014

    • Author(s)
      Kimura T, Watanabe E, Sakamoto T, Takasu O, Ikeda T, Ikeda K, Kotani J, Kitamura N, Sadahiro T, Tateishi Y, Shinozaki K, Oda S
    • Journal Title

      PLoS ONE

      Volume: 9 Pages: e91522

  • [Journal Article] 遺伝子多型に起因する免疫異常と重症敗血症2013

    • Author(s)
      渡邉栄三,織田成人,木村友則,中田孝明,大谷俊介,島田忠長,平澤博之
    • Journal Title

      ICUとCCU

      Volume: 37 Pages: 585-592

  • [Presentation] IRGM遺伝子多型がSevere Sepsis患者の転帰に与える影響2014

    • Author(s)
      木村友則,渡邉栄三,織田成人,坂本照夫,池田寿昭,池田一美,小谷穣治,北村伸哉,立石順久,篠崎広一郎
    • Organizer
      第41回日本集中治療医学会総会・学術集会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2014-02-28
  • [Presentation] An IRGM polymorphism (rs10065172) is associated with mortality of severe sepsis through the down-regulation of IRGM gene expression with LPS challenge2013

    • Author(s)
      Watanabe E, Kimura T, Teratani A, Sakamoto T, Ikeda T, Ikeda K, Kotani J, Kitamura N, Oda S
    • Organizer
      The 11th World Federation of Societies of Intensive and Critical Care Congress 2013
    • Place of Presentation
      Durban, South Africa
    • Year and Date
      2013-08-30
  • [Presentation] Autophagyの重症敗血症における役割とその制御による臨床応用の可能性2013

    • Author(s)
      渡邉栄三,幡野雅彦,仲村将高,高橋和香,木村友則, Paul E Swanson,織田成人
    • Organizer
      第28回日本Shock学会総会2013
    • Place of Presentation
      北里大学薬学部コンベンションホール
    • Year and Date
      2013-05-18
  • [Presentation] IRGM polymorphisms were associated with mortality and IL-6 blood levels of severely septic patients2012

    • Author(s)
      Watanabe E, Kimura T, Teratani A, Sakamoto T, Ikeda T, Ikeda K, Kotani J, Kitamura N, Oda S
    • Organizer
      The 6th International Symposium on Autophagy 2012
    • Place of Presentation
      Okinawa
    • Year and Date
      2012-10-29
  • [Presentation] 敗血症性臓器障害におけるAutophagy-臨床および基礎医学的研究-2012

    • Author(s)
      渡邉栄三,高橋和香,幡野雅彦,織田成人
    • Organizer
      第21回日本Cell Death学会学術集会2012
    • Place of Presentation
      名古屋大学医学部付属病院中央診療棟3階講堂
    • Year and Date
      2012-07-28

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Published: 2015-06-25  

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